Article
Finding disease genes: a fast and flexible approach for analyzing high-throughput data.
European journal of human genetics : EJHG - 1 Oct 2011
Stewart William C L, Drill Esther N, Greenberg David A
Abstract excerpt
Linkage disequilibrium (LD) is the non-random distribution of alleles across the genome, and it can create serious problems for modern linkage studies. In particular, computational feasibility is often obtained at the expense of power, precision, and/or accuracy. In our new approach, we combine linkage results over multiple marker subsets to provide fast, efficient, and robust analyses, without compromising...
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