Article
A robust and efficient statistical method for genetic association studies using case and control samples from multiple cohorts.
BMC genomics - 8 Feb 2013
Wang Minghui, Wang Lin, Jiang Ning, Jia Tianye, Luo Zewei
Abstract excerpt
BACKGROUND: The theoretical basis of genome-wide association studies (GWAS) is statistical inference of linkage disequilibrium (LD) between any polymorphic marker and a putative disease locus. Most methods widely implemented for such analyses are vulnerable to several key demographic factors and deliver a poor statistical power for detecting genuine associations and also a high false positive rate. Here, we...
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