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Article

Identification of causal genes for complex traits.

Bioinformatics (Oxford, England) - 15 Jun 2015

Hormozdiari Farhad, Kichaev Gleb, Yang Wen-Yun, Pasaniuc Bogdan, Eskin Eleazar

Abstract excerpt

MOTIVATION: Although genome-wide association studies (GWAS) have identified thousands of variants associated with common diseases and complex traits, only a handful of these variants are validated to be causal. We consider 'causal variants' as variants which are responsible for the association signal at a locus. As opposed to association studies that benefit from linkage disequilibrium (LD), the main challenge in...

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Identifiers

PMID: 26072484
DOI: 10.1093/bioinformatics/btv240
PMCID: PMC4542778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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