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Article

Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1

27 Aug 2003

Abstract excerpt

The human telomeric DNA binding factor TRF1 (hTRF1) and its interacting proteins TIN2, tankyrase 1 and 2, and PINX1 have been implicated in the regulation of telomerase-dependent telomere length maintenance. Here we show that targeted deletion of exon 1 of the mouse gene encoding Trf1 causes early (day 5 to 6 postcoitus) embryonic lethality. The absence of telomerase did not alter the Terf1(ex1Delta/ex1Delta)...

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Share to Advanced biosensing and bioanalysis techniques
Share to Telomeres, Telomerase, and Senescence

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PMID: 12944479
DOI: 10.1128/mcb.23.18.6533-6541.2003

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Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1PMID 12944479Read ↗

Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells.Semantic proximity Read ↗

TRFH domain is critical for TRF1-mediated telomere stabilization.Semantic proximity Read ↗

Importance of TRF1 for functional telomere structure.Semantic proximity Read ↗

TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells.Semantic proximity Read ↗

Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domainsSemantic proximity Read ↗

Establishment of conditional knockout alleles for the gene encoding the regulator of telomere length (RTEL).Semantic proximity Read ↗

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.Semantic proximity Read ↗

Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita.Semantic proximity Read ↗

Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.Semantic proximity Read ↗

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read ↗

Presence of telomeric G‐strand tails in the telomerase catalytic subunit <i>TERT</i> knockout miceSemantic proximity Read ↗

Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.Semantic proximity Read ↗

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