Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Importance of TRF1 for functional telomere structure.

The Journal of biological chemistry - 9 Jan 2004

Iwano Tomohiko, Tachibana Makoto, Reth Michael, Shinkai Yoichi

Abstract excerpt

Telomeres are comprised of telomeric DNA sequences and associated binding molecules. Their structure functions to protect the ends of linear chromosomes and ensure chromosomal stability. One of the mammalian telomere-binding factors, TRF1, localizes telomeres by binding to double-stranded telomeric DNA arrays. Because the overexpression of wild-type and dominant-negative TRF1 induces progressive telomere...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Embryo, Mammalian
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Fluorescence

Share to Precipitin Tests

Share to Stem Cells

Share to Telomere

Share to Transgenes

Source

Identifiers

PMID: 14559908
DOI: 10.1074/jbc.M309138200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Importance of TRF1 for functional telomere structure.PMID 14559908Read ↗

TRFH domain is critical for TRF1-mediated telomere stabilization.Semantic proximity Read ↗

TIN2 Mediates Functions of TRF2 at Human TelomeresSemantic proximity Read ↗

Role of the TRF2 Telomeric Protein in Cancer and AgingSemantic proximity Read ↗

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.Semantic proximity Read ↗

Control of Human Telomere Length by TRF1 and TRF2Semantic proximity Read ↗

Control of telomere length by the human telomeric protein TRF1.Semantic proximity Read ↗

A Human Telomeric ProteinSemantic proximity Read ↗

TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblastsSemantic proximity Read ↗

Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2Semantic proximity Read ↗

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.Semantic proximity Read ↗

Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere ElongationSemantic proximity Read ↗

Identification and characterization of a TRF2-like telomere-binding protein in ArabidopsisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.