Article
Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America - 29 Jul 2008
Breault David T, Min Irene M, Carlone Diana L, Farilla Loredana G, Ambruzs Dana M, Henderson Daniel E, Algra Selma, Montgomery Robert K, Wagers Amy J, Hole Nicholas
Abstract excerpt
Stem cells hold great promise for regenerative medicine, but remain elusive in many tissues in part because universal markers of "stemness" have not been identified. The ribonucleoprotein complex telomerase catalyzes the extension of chromosome ends, and its expression is associated with failure of cells to undergo cellular senescence. Because such resistance to senescence is a common characteristic of many stem...
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