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Article

Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes.

BMC pulmonary medicine - 4 Jun 2013

Kukkonen Mari K, Tiili Emmi, Vehmas Tapio, Oksa Panu, Piirilä Päivi, Hirvonen Ari

Abstract excerpt

BACKGROUND: The imbalance between proteases and antiproteases has been proposed to participate to the pathogenesis of chronic obstructive pulmonary disease (COPD) and emphysema. Gene level variation in different metalloproteinases, metalloproteinase inhibitors, and cytokines affecting them may co...

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Source

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Identifiers

PMID: 23734748
DOI: 10.1186/1471-2466-13-36
PMCID: PMC3680142

Genes

TGFB1
TIMP2
MMP9
TNF
MMP1
MMP12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23734748-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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