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Article

Genetic variation in TIMP1 but not MMPs predict excess FEV1 decline in two general population-based cohorts.

Respiratory research - 27 Apr 2011

van Diemen C C, Postma D S, Siedlinski M, Blokstra A, Smit H A, Boezen H M

Abstract excerpt

BACKGROUND: An imbalance in matrix metalloproteases (MMPs) and tissue inhibitors of MMPs (TIMPs) contributes to chronic obstructive pulmonary disease (COPD) development. Longitudinal studies investigating Single Nucleotide Polymorphisms (SNPs) in MMPs and TIMPs with respect to COPD development and lung function decline in the general population are lacking. METHODS: We genotyped SNPs in MMP1 (G-1607GG), MMP2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21524282
DOI: 10.1186/1465-9921-12-57
PMCID: PMC3111362

Genes

TIMP1
MMP2
MMP1
MMP12
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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