Article
Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca(2+) channel.
Channels (Austin, Tex.) - 1 Jan 2016
Benmocha Guggenheimer Adva, Almagor Lior, Tsemakhovich Vladimir, Tripathy Debi Ranjan, Hirsch Joel A, Dascal Nathan
Abstract excerpt
The modulation and regulation of voltage-gated Ca(2+) channels is affected by the pore-forming segments, the cytosolic parts of the channel, and interacting intracellular proteins. In this study we demonstrate a direct physical interaction between the N terminus (NT) and C terminus (CT) of the main subunit of the L-type Ca(2+) channel CaV1.2, α1C, and explore the importance of this interaction for the regulation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.