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Article

Endogenous positive allosteric modulation of GABA(A) receptors by diazepam binding inhibitor.

Neuron - 19 Jun 2013

Christian Catherine A, Herbert Anne G, Holt Rebecca L, Peng Kathy, Sherwood Kyla D, Pangratz-Fuehrer Susanne, Rudolph Uwe, Huguenard John R

Abstract excerpt

Benzodiazepines (BZs) allosterically modulate γ-aminobutyric acid type-A receptors (GABAARs) to increase inhibitory synaptic strength. Diazepam binding inhibitor (DBI) protein is a BZ site ligand expressed endogenously in the brain, but functional evidence for BZ-mimicking positive modulatory actions has been elusive. We demonstrate an endogenous potentiation of GABAergic synaptic transmission and responses to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23727119
DOI: 10.1016/j.neuron.2013.04.026
PMCID: PMC3987987

Genes

DBI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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