Article

Tonic Inhibition is Abolished in GABA <sub>A</sub> Receptor γ2R43Q Knock-in Mice with Absence Epilepsy and Febrile Seizures

2017-06-26

Abstract excerpt

<h4>ABSTRACT</h4> The γ2R43Q GABA A receptor mutation confers absence epilepsy in humans, and γ2R43Q knock-in mice (RQ) display absence seizures and generalized spike-and-wave discharges reminiscent of their human counterparts. Previous work on several rodent models led to the conclusion that elevated tonic inhibition in thalamic neurons is necessary and sufficient to produce typical absence epilepsy. In contras...

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Literature Corpus work: 2b03314a-ab69-589a-b145-16667ac5669f
DOI: 10.1101/155556

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