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Article

Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.

Neuropharmacology - 1 Feb 2009

Ying Shui-Wang, Werner David F, Homanics Gregg E, Harrison Neil L, Goldstein Peter A

Abstract excerpt

GABAergic neurons in the reticular thalamic nucleus (RTN) synapse onto thalamocortical neurons in the ventrobasal (VB) thalamus, and this reticulo-thalamocortical pathway is considered an anatomic target for general anesthetic-induced unconsciousness. A mutant mouse was engineered to harbor two amino acid substitutions (S270H, L277A) in the GABA(A) receptor (GABA(A)-R) alpha1 subunit; this mutation abolished...

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Source

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Identifiers

PMID: 18948126
DOI: 10.1016/j.neuropharm.2008.09.015
PMCID: PMC2668243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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