Article

Excitatory GABAergic signalling is associated with acquired benzodiazepine resistance in status epilepticus

2018-11-30

Abstract excerpt

Status epilepticus (SE) is defined as a state of unrelenting seizure activity. Generalised convulsive SE is associated with a rapidly rising mortality rate, and thus constitutes a medical emergency. Benzodiazepines, which act as positive modulators of chloride (Cl - ) permeable GABA A receptors, are indicated as first-line treatment, but this is ineffective in many cases. We found that 48% of children presenting...

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Literature Corpus work: c14e1bf7-fb63-5225-91ac-bf70acb1c31d
DOI: 10.1101/478594

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