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Article

Variants in GBA, SNCA, and MAPT influence Parkinson disease risk, age at onset, and progression.

Neurobiology of aging - 1 Jan 2016

Davis Albert A, Andruska Kristin M, Benitez Bruno A, Racette Brad A, Perlmutter Joel S, Cruchaga Carlos

Abstract excerpt

Multiple genetic variants have been linked to risk of Parkinson disease (PD), but known mutations do not explain a large proportion of the total PD cases. Similarly, multiple loci have been associated with PD risk by genome-wide association studies (GWAS). The influence that genetic factors confer on phenotypic diversity remains unclear. Few studies have been performed to determine whether the GWAS loci are also...

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Source

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Identifiers

PMID: 26601739
DOI: 10.1016/j.neurobiolaging.2015.09.014
PMCID: PMC4688052

Genes

MAPT
SNCA
ACMSD
GAK
LAMP3
MCCC1
STK39

Provenance

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