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Article

Genotype-phenotype analysis of S326C OGG1 polymorphism: a risk factor for oxidative pathologies.

Free radical biology & medicine - 1 Oct 2013

Simonelli Valeria, Camerini Serena, Mazzei Filomena, Van Loon Barbara, Allione Alessandra, D'Errico Mariarosaria, Barone Flavia, Minoprio Anna, Ricceri Fulvio, Guarrera Simonetta, Russo Alessia, Dalhus Bjørn, Crescenzi Marco, Hübscher Ulrich, Bjørås Magnar, Matullo Giuseppe, Dogliotti Eugenia

Abstract excerpt

8-Oxoguanine DNA glycosylase (OGG) activity was measured by an in vitro assay in lymphocytes of healthy volunteers genotyped for various OGG1 polymorphisms. Only homozygous carriers of the polymorphic C326 allele showed a significantly lower OGG activity compared to the homozygous S326 genotype. The purified S326C OGG1 showed a decreased ability to complete the repair synthesis step in a base excision repair...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23726996
DOI: 10.1016/j.freeradbiomed.2013.05.031

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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