Article
Gene susceptibility to oxidative damage: from single nucleotide polymorphisms to function.
Mutation research - 1 Mar 2012
Simonelli Valeria, Mazzei Filomena, D'Errico Mariarosaria, Dogliotti Eugenia
Abstract excerpt
Oxidative damage to DNA can cause mutations, and mutations can lead to cancer. DNA repair of oxidative damage should therefore play a pivotal role in defending humans against cancer. This is exemplified by the increased risk of colorectal cancer of patients with germ-line mutations of the oxidative damage DNA glycosylase MUTYH. In contrast to germ-line mutations in DNA repair genes, which cause a strong...
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