Inactivation of a common OGG1 variant by TNF-alpha in mammalian cells.

Abstract excerpt

Reactive oxygen species threaten genomic integrity by inducing oxidative DNA damage. One common form of oxidative DNA damage is the mutagenic lesion 8-oxoguanine (8-oxodG). One driver of oxidative stress that can induce 8-oxodG is inflammation, which can be initiated by the cytokine tumor necrosis factor alpha (TNF-α). Oxidative DNA damage is primarily repaired by the base excision repair pathway, initiated by...

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• Oxidation-Reduction
• Hydrogen Peroxide
• Cell Line, Transformed
• DNA Glycosylases
• Gene Knockdown Techniques