Article
OGG1 polymorphisms and breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2006
Rossner Pavel, Terry Mary Beth, Gammon Marilie D, Zhang Fang Fang, Teitelbaum Susan L, Eng Sybil M, Sagiv Sharon K, Gaudet Mia M, Neugut Alfred I, Santella Regina M
Abstract excerpt
The role of oxidative stress in breast cancer risk is still unclear. OGG1 encodes an 8-oxoguanine DNA glycosylase/AP lyase that catalyzes the removal of 8-oxodeoxyguanosine from DNA. 8-Oxodeoxyguanosine, the most abundant lesion generated by oxidative stress, is highly mutagenic. Environmental sources of oxidative stress, such as alcohol consumption, cigarette smoking, high body mass index (BMI), and low fruits...
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