Article
The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jan 2012
Balko Justin M, Miller Todd W, Morrison Meghan M, Hutchinson Katherine, Young Christian, Rinehart Cammie, Sánchez Violeta, Jee David, Polyak Kornelia, Prat Aleix, Perou Charles M, Arteaga Carlos L, Cook Rebecca S
Abstract excerpt
ErbB3 harbors weak kinase activity, but strongly activates downstream phosphatidylinositol 3-kinase/Akt signaling through heterodimerization with and activation by other ErbB receptor tyrosine kinases. We report here that ErbB3 loss in the luminal mammary epithelium of mice impaired Akt and MAPK signaling and reduced luminal cell proliferation and survival. ERBB3 mRNA expression levels were highest in luminal...
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