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Article

Loss of LRIG1 locus increases risk of early and late relapse of stage I/II breast cancer.

Cancer research - 1 Jun 2014

Thompson Patricia A, Ljuslinder Ingrid, Tsavachidis Spyros, Brewster Abenaa, Sahin Aysegul, Hedman Håkan, Henriksson Roger, Bondy Melissa L, Melin Beatrice S

Abstract excerpt

Gains and losses at chromosome 3p12-21 are common in breast tumors and associated with patient outcomes. We hypothesized that the LRIG1 gene at 3p14.1, whose product functions in ErbB-family member degradation, is a critical tumor modifier at this locus. We analyzed 971 stage I/II breast tumors using Affymetrix Oncoscan molecular inversion probe arrays that include 12 probes located within LRIG1. Copy number...

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Identifiers

PMID: 24879564
DOI: 10.1158/0008-5472.CAN-13-2112
PMCID: PMC8759715

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