Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII.

Oncogene - 25 Sept 2008

Stutz M A, Shattuck D L, Laederich M B, Carraway K L, Sweeney C

Abstract excerpt

Epidermal growth factor receptor (EGFR) mutation is frequently observed in human cancer and contributes to the growth, survival and therapeutic resistance of tumors. EGFRvIII is an oncogenic EGFR mutant resulting from the deletion of exons 2-7 and is the most common EGFR mutant observed in glioblastoma multiforme, an aggressive brain tumor. EGFRvIII is constitutively active but poorly ubiquitinated, leading to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to ErbB Receptors
Share to EGF gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Membrane Glycoproteins

Share to Mutation

Share to Phosphorylation

Share to Proto-Oncogene Proteins c-cbl

Source

Open in PubMed Open full text

Identifiers

PMID: 18542056
DOI: 10.1038/onc.2008.185
PMCID: PMC3175812

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII.PMID 18542056Read ↗

Opposing effect of EGFRWT on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch.Semantic proximity Read ↗

The epidermal growth factor receptor variant <scp>III</scp> (<scp>EGFR</scp>v<scp>III</scp>): where wild things are alteredSemantic proximity Read ↗

Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3).Semantic proximity Read ↗

LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL.Semantic proximity Read ↗

Mutant epidermal growth factor receptors as targets for cancer therapy.Semantic proximity Read ↗

Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR.Semantic proximity Read ↗

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesisSemantic proximity Read ↗

Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutantsSemantic proximity Read ↗

Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation.Semantic proximity Read ↗

Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.Semantic proximity Read ↗

Transmembrane CLIC1 sustains EGFRvIII–STAT3 oncogenic signaling in Glioblastoma through interaction with OSMRSemantic proximity Read ↗

Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.