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LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer

2 Dec 2019

Abstract excerpt

Abstract LRIG1 has been reported to be a tumor suppressor in gastrointestinal tract and epidermis. However, little is known about the expression, regulation and biological functions of LRIG1 in prostate cancer (PCa). We find that LRIG1 is overexpressed in PCa, but its expression correlates with better patient survival. Functional studies reveal strong tumor-suppressive functions of LRIG1 in both AR+ and AR−...

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PMID: 31792211
DOI: 10.1038/s41467-019-13532-4

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