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Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR.

Carcinogenesis - 3 May 2018

Torigoe Hidejiro, Yamamoto Hiromasa, Sakaguchi Masakiyo, Youyi Chen, Namba Kei, Sato Hiroki, Shien Kazuhiko, Soh Junichi, Suzawa Ken, Tomida Shuta, Tsukuda Kazunori, Miyoshi Shinichiro, Toyooka Shinichi

Abstract excerpt

Epidermal growth factor receptor (EGFR) is a member of the ErbB (HER) family that is known to play important roles in the pathogenesis of various human cancers. Mutations of the EGFR gene are commonly found as oncogenic driver mutations and have been targeted for treatment of non-small cell lung cancer (NSCLC). Leucine-rich repeat and immunoglobulin-like domain protein-1 (LRIG1) is a cell-surface protein that is...

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PMID: 29546323
DOI: 10.1093/carcin/bgy044

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EGFR
MET

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Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR.PMID 29546323Read ↗

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