Article
Transgenic expression of the FTDP-17 tauV337M mutation in brain dissociates components of executive function in mice.
Neurobiology of learning and memory - 1 Sept 2013
Reichelt A C, Killcross S, Wilkinson L S, Humby T, Good M A
Abstract excerpt
Frontotemporal lobe dementia (FTD) is a heterogeneous range of disorders, a subset of which arise from fully penetrant, autosomal dominant point mutations in the gene coding for the microtubule associated protein tau. These genetic tauopathies are associated with complex behavioural/cognitive disturbances, including compromised executive function. In the present study, we modelled the effects of the FTD with...
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