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Article

Cognitive phenotyping of amyloid precursor protein transgenic J20 mice.

Behavioural brain research - 17 Mar 2012

Karl Tim, Bhatia Surabhi, Cheng David, Kim Woojin Scott, Garner Brett

Abstract excerpt

Transgenic mice that express familial Alzheimer's disease mutant forms of the human amyloid precursor protein (hAPP) have proved to be invaluable in determining the impact that the neurotoxic amyloid-β peptide has in vivo. In addition to the propensity to accumulate cerebral amyloid plaques, a crucial characteristic of hAPP mouse models is their cognitive impairments. To date the most widely used test for...

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PMID: 22197298
DOI: 10.1016/j.bbr.2011.12.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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