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Article

Behavioural inflexibility in a comorbid rat model of striatal ischemic injury and mutant hAPP overexpression.

Behavioural brain research - 30 Aug 2017

Levit Alexander, Regis Aaron M, Garabon Jessica R, Oh Seung-Hun, Desai Sagar J, Rajakumar Nagalingam, Hachinski Vladimir, Agca Yuksel, Agca Cansu, Whitehead Shawn N, Allman Brian L

Abstract excerpt

Alzheimer disease (AD) and stroke coexist and interact; yet how they interact is not sufficiently understood. Both AD and basal ganglia stroke can impair behavioural flexibility, which can be reliably modeled in rats using an established operant based set-shifting test. Transgenic Fischer 344-APP21 rats (TgF344) overexpress pathogenic human amyloid precursor protein (hAPP) but do not spontaneously develop overt...

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PMID: 28693862
DOI: 10.1016/j.bbr.2017.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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