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Article

Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene.

Scientific reports - 1 Oct 2015

Nithianantharajah J, McKechanie A G, Stewart T J, Johnstone M, Blackwood D H, St Clair D, Grant S G N, Bussey T J, Saksida L M

Abstract excerpt

Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in...

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Identifiers

PMID: 26423861
DOI: 10.1038/srep14613
PMCID: PMC4589696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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