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Article

Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS-FTD.

Translational psychiatry - 4 Nov 2020

Kim Eosu, White Matthew A, Phillips Benjamin U, Lopez-Cruz Laura, Kim Hyunjeong, Heath Christopher J, Lee Jong Eun, Saksida Lisa M, Sreedharan Jemeen, Bussey Timothy J

Abstract excerpt

Perseveration and apathy are two of the most common behavioural and psychological symptoms of dementia (BPSDs) in amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD). Availability of a validated and behaviourally characterised animal model is crucial for translational research into BPSD in the FTD context. We behaviourally evaluated the male TDP-43Q331K mouse, an ALS-FTD model with a human-equivalent...

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Identifiers

PMID: 33149110
DOI: 10.1038/s41398-020-01078-9
PMCID: PMC7643138

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VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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