Article
Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter
28 Jul 2014
Abstract excerpt
The influenza virus is a major human and animal pathogen responsible for seasonal epidemics and occasional pandemics. The genome of the influenza A virus comprises eight segments of single-stranded, negative-sense RNA with highly conserved 5' and 3' termini. These termini interact to form a double-stranded promoter structure that is recognized and bound by the viral RNA-dependent RNA polymerase (RNAP); however,...
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