Article
Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish.
Disease models & mechanisms - 1 Sept 2013
Choorapoikayil Suma, Weijts Bart, Kers Rianne, de Bruin Alain, den Hertog Jeroen
Abstract excerpt
Angiogenesis, the emergence of vessels from an existing vascular network, is pathologically associated with tumor progression and is of great interest for therapeutic intervention. PTEN is a frequently mutated tumor suppressor and has been linked to the progression of many types of tumors, including hemangiosarcomas in zebrafish. Here, we report that mutant zebrafish embryos lacking functional Pten exhibit...
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