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Article

Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling.

Developmental biology - 1 Jun 2022

Lange Martin, Ohnesorge Nils, Hoffmann Dennis, Rocha Susana F, Benedito Rui, Siekmann Arndt F

Abstract excerpt

The formation of appropriately patterned blood vessel networks requires endothelial cell migration and proliferation. Signaling through the Vascular Endothelial Growth Factor A (VEGFA) pathway is instrumental in coordinating these processes. mRNA splicing generates short (diffusible) and long (extracellular matrix bound) Vegfa isoforms. The differences between these isoforms in controlling cellular functions are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35337795
DOI: 10.1016/j.ydbio.2022.03.006
PMCID: PMC11238767

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