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Article

PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis.

Cellular signalling - 1 Dec 2007

Fang Jing, Ding Min, Yang Lily, Liu Ling-Zhi, Jiang Bing-Hua

Abstract excerpt

PI3K pathway exerts its function through its downstream molecule AKT in regulating various cell functions including cell proliferation, cell transformation, cell apoptosis, tumor growth and angiogenesis. PTEN is an inhibitor of PI3K, and its loss or mutation is common in human prostate cancer. But the direct role and mechanism of PI3K/PTEN signaling in regulating angiogenesis and tumor growth in vivo remain to be...

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Source

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Identifiers

PMID: 17826033
DOI: 10.1016/j.cellsig.2007.07.025
PMCID: PMC2094004

Genes

PTEN
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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