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Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish

25 Jun 2009

Abstract excerpt

The zebrafish has become an important model for cancer research. Several cancer models have been established by transgenic expression of human or mouse oncogenes in zebrafish. Since it is amenable to efficient transgenesis, zebrafish have immense potential to be used for studying interaction of oncogenes and pathways at the organismal level. Using the Gal4VP16-UAS binary transgenic expression approach, we...

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PMID: 19555497
DOI: 10.1186/1476-4598-8-40

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