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Article

Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.

PloS one - 1 Jan 2016

Stumpf Miriam, den Hertog Jeroen

Abstract excerpt

The lipid- and protein phosphatase PTEN is one of the most frequently mutated tumor suppressor genes in human cancers and many mutations found in tumor samples directly affect PTEN phosphatase activity. In order to understand the functional consequences of these mutations in vivo, the aim of our study was to dissect the role of Pten phosphatase activities during zebrafish embryonic development. As in other model...

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Topics

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Share to Amino Acid Sequence
Share to Embryo, Nonmammalian
Share to Lipid Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Physiologic

Share to Phosphoproteins

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

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Source

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Identifiers

PMID: 26848951
DOI: 10.1371/journal.pone.0148508
PMCID: PMC4743836

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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