Mature Purkinje cells require the retinoic acid-related orphan receptor-α (RORα) to maintain climbing fiber mono-innervation and other adult characteristics.

doi:10.1523/JNEUROSCI.2977-12.2013

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Article

Mature Purkinje cells require the retinoic acid-related orphan receptor-α (RORα) to maintain climbing fiber mono-innervation and other adult characteristics.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 May 2013

Chen Xiao Ru, Heck Nicolas, Lohof Ann M, Rochefort Christelle, Morel Marie-Pierre, Wehrlé Rosine, Doulazmi Mohamed, Marty Serge, Cannaya Vidjeacoumary, Avci Hasan X, Mariani Jean, Rondi-Reig Laure, Vodjdani Guilan, Sherrard Rachel M, Sotelo Constantino, Dusart Isabelle

Abstract excerpt

Neuronal maturation during development is a multistep process regulated by transcription factors. The transcription factor RORα (retinoic acid-related orphan receptor α) is necessary for early Purkinje cell (PC) maturation but is also expressed throughout adulthood. To identify the role of RORα in mature PCs, we used Cre-lox mouse genetic tools in vivo that delete it specifically from PCs between postnatal days...

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PMID: 23719821
DOI: 10.1523/JNEUROSCI.2977-12.2013
PMCID: PMC6618556

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