Article
An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons.
Nature communications - 1 Jan 2013
Liu Hong, Kim Soo-Young, Fu Yulong, Wu Xuefeng, Ng Lily, Swaroop Anand, Forrest Douglas
Abstract excerpt
Amacrine and horizontal interneurons integrate visual information as it is relayed through the retina from the photoreceptors to the ganglion cells. The early steps that generate these interneuron networks remain unclear. Here we show that a distinct retinoid-related orphan nuclear receptor β1 (RORβ1) isoform encoded by the retinoid-related orphan nuclear receptor β gene (Rorb) is critical for both amacrine and...
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