Article
The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells.
Developmental biology - 1 Apr 2014
Nakatani Tomoya, Minaki Yasuko, Kumai Minoru, Nitta Chiemi, Ono Yuichi
Abstract excerpt
Purkinje cells (PCs) provide the primary output from the cerebellar cortex, which controls movement and posture, and loss of PCs causes severe cerebellar dysfunction. The mechanisms underlying cell fate determination and early differentiation of PC remain largely unknown. Here we show that the c-Ski family member and transcriptional regulator Corl2 is required for correct differentiation of PCs. In Corl2...
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