Article
Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells.
Cerebellum (London, England) - 1 Feb 2014
Konno Ayumu, Shuvaev Anton N, Miyake Noriko, Miyake Koichi, Iizuka Akira, Matsuura Serina, Huda Fathul, Nakamura Kazuhiro, Yanagi Shigeru, Shimada Takashi, Hirai Hirokazu
Abstract excerpt
Spinocerebellar ataxia type 3 (SCA3) is caused by the abnormal expansion of CAG repeats within the ataxin-3 gene. Previously, we generated transgenic mice (SCA3 mice) that express a truncated form of ataxin-3 containing abnormally expanded CAG repeats specifically in cerebellar Purkinje cells (PC...
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