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Article

Genetic instability in human embryonic stem cells: prospects and caveats.

Future oncology (London, England) - 1 Jun 2013

Nouspikel Thierry

Abstract excerpt

Human embryonic stem cells (hESCs) display a leaky G1/S checkpoint and inefficient nucleotide excision repair activity. Maintenance of genomic stability in these cells mostly relies on the elimination of damaged cells by high rates of apoptosis. However, a subpopulation survives and proliferates actively, bypassing DNA damage by translesion synthesis, a known mutagenic process. Indeed, high levels of...

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Identifiers

PMID: 23718307
DOI: 10.2217/fon.13.22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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