Article
The Bright and the Dark Sides of DNA Repair in Stem Cells
1 Jan 2010
Abstract excerpt
DNA repair is a double-edged sword in stem cells. It protects normal stem cells in both embryonic and adult tissues from genetic damage, thus allowing perpetuation of intact genomes into new tissues. Fast and efficient DNA repair mechanisms have evolved in normal stem and progenitor cells. Upon differentiation, a certain degree of somatic mutations becomes more acceptable and, consequently, DNA repair dims. DNA...
Topics
Join the communities discussing this publication.