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Article

Disseminated and rapidly fatal tuberculosis in mice bearing a defective allele at IFN regulatory factor 8.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2009

Marquis Jean-François, LaCourse Ronald, Ryan Lynn, North Robert J, Gros Philippe

Abstract excerpt

The interferon regulatory factor (IRF) family member IRF-8 participates in IFN-gamma-dependent transcriptional activation of genes containing in their promoter regions IFN-stimulated response element or IFN-gamma activation site elements. To test the role of IRF-8 in host defenses against tuberculosis, BXH-2 mice, which bear a defective IRF-8(R294C) allele, were challenged with low doses of virulent Mycobacterium...

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Identifiers

PMID: 19234196
DOI: 10.4049/jimmunol.0800680
PMCID: PMC4307599

Genes

NOS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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