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Article

A single center analysis of nucleophosmin in acute myeloid leukemia: value of combining immunohistochemistry with molecular mutation analysis.

Haematologica - 1 Oct 2013

Woolthuis Carolien M, Mulder André B, Verkaik-Schakel Rikst Nynke, Rosati Stefano, Diepstra Arjan, van den Berg Eva, Schuringa Jan Jacob, Vellenga Edo, Kluin Philip M, Huls Gerwin

Abstract excerpt

Mutations of nucleophosmin 1 are frequently found in acute myeloid leukemia and lead to aberrant cytoplasmic accumulation of nucleophosmin protein. Immunohistochemical staining is therefore recommended as the technique of choice in front-line screening. In this study, we assessed the sensitivity and specificity of immunohistochemistry on formalin-fixed bone marrow biopsies compared with gold standard molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23716555
DOI: 10.3324/haematol.2012.079806
PMCID: PMC3789457

Genes

MLF1

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