Article

Wild-Type p53 Overexpression in NPM1-Mutated AML: Potential Implications for Disease Biology and Therapy Response

2024-10-09

Abstract excerpt

<title>Abstract</title> <p>Somatic mutations in nucleophosmin (<italic>NPM1</italic>) are key in defining a common subtype of acute myeloid leukemia (<italic>NPM1</italic>-AML), characterized by chromosomal stability and favorable therapeutic responses. However, some patients exhibit a suboptimal response to initial treatment, and relapses are common, highlighting the need for novel biomarkers. Notably, <italic>N...

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Literature Corpus work: 2e581e46-82d8-5d4f-aee5-e4d38b66cf15
DOI: 10.21203/rs.3.rs-5214655/v1

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