Article
Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis.
Cancer - 15 Oct 2009
Konoplev Sergej, Huang Xuelin, Drabkin Harry A, Koeppen Hartmut, Jones Dan, Kantarjian Hagop M, Garcia-Manero Guillermo, Chen Weina, Medeiros L Jeffrey, Bueso-Ramos Carlos E
Abstract excerpt
BACKGROUND: Nucleophosmin (NPM1) gene mutations are reported to predict a favorable prognosis in acute myeloid leukemia (AML) patients. Aberrant cytoplasmic localization of nucleophosmin (NPM) protein is reported be a surrogate for NPM1 gene mutation. METHODS: Using immunohistochemical (IHC) anal...
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