Article
[Immunohistochemical demonstration of mutant nucleophosmin in acute myeloid leukemia: biological and clinical features related to NPMc expression].
Orvosi hetilap - 31 May 2009
Bedekovics Judit, Rejto László, Telek Béla, Udvardy Miklós, Ujfalusi Anikó, Oláh Eva, Hevessy Zsuzsa, Kappelmayer János, Kajtár Béla, Méhes Gábor
Abstract excerpt
The mutation of the nucleophosmin gene (NPM1) is the most frequently occurring genetic aberration in acute myeloid leukemia (AML). Due to the high frequency and the obvious impact on disease outcome, the current WHO classification also defines the new (tentative) entity of "AML with NPM mutation". Mutations of NPM1 exon 12 affect both nuclear complexion and nuclear export signaling (NES) domain resulting in...
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