Article
Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification.
Blood - 15 Dec 2006
Pasqualucci Laura, Liso Arcangelo, Martelli Maria Paola, Bolli Niccolò, Pacini Roberta, Tabarrini Alessia, Carini Manola, Bigerna Barbara, Pucciarini Alessandra, Mannucci Roberta, Nicoletti Ildo, Tiacci Enrico, Meloni Giovanna, Specchia Giorgina, Cantore Nicola, Di Raimondo Francesco, Pileri Stefano, Mecucci Cristina, Mandelli Franco, Martelli Massimo Fabrizio, Falini Brunangelo
Abstract excerpt
Because of a lack of specific clonality markers, information on lineage involvement and cell of origin of acute myeloid leukemia with normal karyotype (AML-NK), is missing. Because Nucleophosmin (NPM) gene is frequently mutated in AML-NK and causes aberrant NPM cytoplasmic localization (NPMc+), it was used as an AML lineage clonality marker. Clonal NPM exon 12 mutations were detected in myeloid, monocytic,...
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