Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia.

doi:10.1182/blood-2006-03-007013

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia.

Blood - 15 Sept 2006

Falini Brunangelo, Martelli Maria Paola, Bolli Niccolò, Bonasso Rossella, Ghia Emanuela, Pallotta Maria Teresa, Diverio Daniela, Nicoletti Ildo, Pacini Roberta, Tabarrini Alessia, Galletti Barbara Verducci, Mannucci Roberta, Roti Giovanni, Rosati Roberto, Specchia Giorgina, Liso Arcangelo, Tiacci Enrico, Alcalay Myriam, Luzi Lucilla, Volorio Sara, Bernard Loris, Guarini Anna, Amadori Sergio, Mandelli Franco, Pane Fabrizio, Lo-Coco Francesco, Saglio Giuseppe, Pelicci Pier-Giuseppe, Martelli Massimo F, Mecucci Cristina

Abstract excerpt

Nucleophosmin (NPM) exon-12 mutations occur in 50% to 60% of adult acute myeloid leukemia (AML) with normal karyotype and are predictors of favorable prognosis. We evaluated bone marrow or peripheral blood samples from 450 adult patients with AML of the GIMEMA (Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto)/AML12 EORTC (European Organization for Research and Treatment of Cancer) trial to (1) search...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoplasm

Share to DNA, Neoplasm

Share to Leukemia, Myeloid, Acute

Share to Nuclear Export Signals

Share to Nuclear Proteins

Share to Nucleophosmin

Share to Tryptophan

Source

Open in PubMed

Identifiers

PMID: 16720834
DOI: 10.1182/blood-2006-03-007013

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia.PMID 16720834Read ↗

Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features.Semantic proximity Read ↗

Novel NPM1 exon 5 mutations and gene fusions leading to aberrant cytoplasmic nucleophosmin in AML.Semantic proximity Read ↗

A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML).Semantic proximity Read ↗

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.Semantic proximity Read ↗

[Immunohistochemical demonstration of mutant nucleophosmin in acute myeloid leukemia: biological and clinical features related to NPMc expression].Semantic proximity Read ↗

Acute myeloid leukemia with mutated nucleophosmin (NPM1): molecular, pathological, and clinical features.Semantic proximity Read ↗

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.Semantic proximity Read ↗

Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity.Semantic proximity Read ↗

NPM1-mutated acute myeloid leukemia: New pathogenetic and therapeutic insights and open questions.Semantic proximity Read ↗

Cytoplasmic expression of nucleophosmin accurately predicts mutation in the nucleophosmin gene in patients with acute myeloid leukemia and normal karyotype.Semantic proximity Read ↗

NPM1-mutated acute myeloid leukemia: from bench to bedside.Semantic proximity Read ↗

The clinicopathologic significance of NPM1 mutation and ability to detect mutated NPM1 by immunohistochemistry in non-AML myeloid neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.