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Article

The catalytic mechanism of vitamin K epoxide reduction in a cellular environment.

The Journal of biological chemistry - 1 Jan 2000

Shen Guomin, Cui Weidong, Cao Qing, Gao Meng, Liu Hongli, Su Gaigai, Gross Michael L, Li Weikai

Abstract excerpt

Vitamin K epoxide reductases (VKORs) constitute a major family of integral membrane thiol oxidoreductases. In humans, VKOR sustains blood coagulation and bone mineralization through the vitamin K cycle. Previous chemical models assumed that the catalysis of human VKOR (hVKOR) starts from a fully reduced active site. This state, however, constitutes only a minor cellular fraction (5.6%). Thus, the mechanism...

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Identifiers

PMID: 33273012
DOI: 10.1074/jbc.RA120.015401
PMCID: PMC7895805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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