Article

The vitamin K oxidoreductase VKORC1L1 prevents oxidative stress in hepatocytes and protects from MASLD and hepatocellular carcinoma

2026-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Generation of vitamin K hydroxyquinone (VKH 2 ) by vitamin K oxidoreductase 1 (VKORC1) is essential for the γ-carboxylation of clotting factors by hepatocytes. Here, we uncover a non-redundant function of the vitamin K oxidoreductase paralogue VKORC1L1 in liver homeostasis. Mice lacking Vkorc1l1 globally or specifically in hepatocytes exhibit normal coagulation yet develop progressive metaboli...

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Literature Corpus work: 095c2b50-2308-5a4f-943c-66e98e947e04
DOI: 10.64898/2026.02.25.707953

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