Article

Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves

2019-05-17

Abstract excerpt

Acid sensing in the gastrointestinal tract is required for gut homeostasis and the detection of tissue acidosis caused by ischaemia, inflammation and infection. In the colorectum, activation of colonic afferents by low pH contributes to visceral hypersensitivity and abdominal pain in human disease including during inflammatory bowel disease. The naked mole-rat ( Heterocephalus glaber ; NMR) shows no pain-related...

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Literature Corpus work: 380a2be9-d79f-50df-92d5-8ebda27c7b0a
DOI: 10.1101/636571

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